PAPEL DOS HORMÔNIOS SEXUAIS NA INFECÇÃO POR COVID-19
DOI:
https://doi.org/10.29327/213319.23.5-3Keywords:
COVID-19, Hormônios sexuais, InfluênciaAbstract
Após o surgimento dos primeiros relatos sobre a COVID-19 e o estudo mais aprofundado dessa doença, ficou evidente que a razão de óbitos entre pacientes do sexo masculino e feminino era diferente: homens tinham piores desfechos clínicos que mulheres. Assim, elucidar qual é o papel dos hormônios sexuais na contaminação pelo COVID-19 e como o perfil hormonal dos pacientes pode influenciar no prognóstico dos mesmos é o foco desse estudo. Trata-se de uma revisão integrativa com busca dos dados nas bases PubMed e Biblioteca Virtual em Saúde (BVS). Nove artigos foram selecionados para compor a pesquisa com a utilização dos descritores “Hormones, Gonadal Steroid”, “SARS-CoV-2 Infection” e seus sinônimos. Foram critérios de inclusão as publicações dos últimos cinco anos, nos idiomas português, inglês ou espanhol. Os resultados e a conclusão apontam que o sexo masculino apresenta maior incidência de comorbidades e que a testosterona atua como potencializador da infecção pelo vírus e influencia no prognóstico, já as mulheres possuem uma resposta imune mais eficiente, sendo o estrogênio um importante fator protetivo contra a infecção. Contudo, são necessários mais estudos que busquem esclarecer com maior precisão a natureza multifatorial dessa interação.
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